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In a perivascular adipose tissue inflammation model, macrophages deficient in SIRT3 exhibited a metabolic switch from oxidative phosphorylation to glycolysis, resulting in lactate accumulation and subsequent promotion of NLRP3 inflammasome activation and IL-1 secretion (133).In summary, the regulation of the NLRP3 inflammasome by lactate is not unidirectional

W.MilaneschiY.LamersF.VogelzangsN

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Selenium-rich foods, such as Brazil nuts, further assist the body in synthesizing this vital molecule

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